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The presence of both a glycosomal ATP- dependent PFK with PPi-dependent char- acteristics (see above), together with a PPi-dependent PPDK, suggests that an ances- tral trypanosomatid may have possessed a PPi-dependent type of glycolysis, similar to what is still encountered in some anaerobic protists, such as Giardia and Entamoeba (Chapter 7, part 1). [438, 449, 452, 466, 475, 477, 484] Brans, C.
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